Lyrica pregabalin for Fibromyalgia: Uses, Dosage, Side Effects, Interactions, Warnings

While the 2.5 mg/kg/day group performed numerically better than placebo, this difference was not statistically significant. Based on animal studies, there is a potential risk of tumorigenicity with pregabalin exposure via breast milk to the breastfed infant [see Nonclinical Toxicology]. Available clinical study data in patients greater than 12 years of age do not provide a clear conclusion about the potential risk of tumorigenicity with pregabalin [see WARNINGS AND PRECAUTIONS].

The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988. If you’re concerned about sexual side effects during your Lyrica treatment, talk with your doctor.

Dosage for diabetic nerve pain

So efforts are needed to support the addition of this drug to the controlled drug list (which can’t be purchased without prescription in Jordan). In order to support this requirement, we aimed in this observational study to provide background data regarding the abuse/misuse of pregabalin lyrica products in a community pharmacy setting in Jordan. Up to the researchers’ knowledge, this is the first study of its kind in Jordan to address this issue. Pregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder, neuropathic pain and fibromyalgia.

• If visual disturbance persists, consider further assessment.
• Talk to your care team about the use of this medication in children.
• The most common dose-related adverse reactions (≥5%) with LYRICA in this study were somnolence, pneumonia, and viral infection [see ADVERSE REACTIONS].
• Among the LYRICA-treated patients, 97% completed the double-blind phase of the study.
• Small amounts of pregabalin have been detected in the milk of lactating women.

The effect on offspring survival was pronounced at doses greater than or equal to 1250 mg/kg, with 100% mortality in high-dose litters. The no-effect dose for pre- and postnatal developmental toxicity in rats (50 mg/kg) produced a plasma exposure approximately 2 times human exposure at the MRD. Advise patients to avoid consuming alcohol while taking LYRICA, as LYRICA may potentiate the impairment of motor skills and sedating effects of alcohol. In clinical studies across various patient populations, comprising 6396 patient-years of exposure in patients greater than 12 years of age, new or worsening-preexisting tumors were reported in 57 patients. Without knowledge of the background incidence and recurrence in similar populations not treated with LYRICA, it is impossible to know whether the incidence seen in these cohorts is or is not affected by treatment.

CLINICAL PHARMACOLOGY

You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. You may have a higher chance for dizziness and sleepiness if you take LYRICA with alcohol, narcotic pain medicines, or medicines for anxiety. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. If you’re taking a thiazolidinedione, talk with your doctor before taking Lyrica. If you take these drugs together, your doctor will likely monitor you for any symptoms of swelling or unusual weight gain.

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Administer the total daily dosage orally in two or three divided doses as indicated in Table 1. In pediatric patients, the recommended dosing regimen is dependent upon body weight. Based on clinical response and tolerability, dosage may be increased, approximately weekly. Following oral administration, pregabalin reaches peak plasma concentration at 0.5 hours to 2 hours in the fasted state. Both apparent clearance (CL/F) and apparent volume of distribution increase as body weight increases. The mean t½ is 3 to 4 hours in pediatric subjects up to 6 years of age, and 4 to 6 hours in those 7 years of age and older.

Additional information about Lyrica’s dosage is described in this article. Then, they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. If you have questions about treating anxiety, including the Lyrica dosage for anxiety that may be right for you, talk with your doctor. Lyrica isn’t FDA-approved to treat anxiety, such as generalized anxiety disorder (GAD). However, the medication may be used off-label for this purpose.

This program is not valid when the entire cost of your prescription drug is eligible to be reimbursed by your private insurance plan or other private health or pharmacy benefit programs. You must deduct the value received under this program from any reimbursement request submitted to your private insurance plan, either directly by you or on your behalf. You are responsible for reporting use of this program to any private insurer, health plan, or other third party who pays for or reimburses any part of the prescription filled using the program, as may be required. You should not use the program if your insurer or health plan prohibits use of manufacturer co-pay cards. You must be 18 years of age or older to accept this offer. In clinical trials, some adults taking Lyrica for nerve pain or fibromyalgia reported a decrease in pain within 1 week of starting treatment.

With complex partial seizures, a person loses consciousness. People with diabetes have high levels of glucose (sugar) in their blood. Over time, high blood sugar levels can damage your nerves. Your nerves help your body move, communicate, breathe, and much more. If you have new or worsening depression or thoughts of suicide while taking Lyrica, talk with your doctor right away. They may recommend that you switch to a different medication to treat your condition.

If recommended by your doctor, you may be able to receive a 90-day supply of Lyrica. This means there should be less of a concern about running out of the medication. If you’re interested in this option, check with your doctor and your insurance company. Some Medicare plans may help cover the cost of mail-order medications. Drinking alcohol during your Lyrica treatment could raise your risk for certain side effects, such as dizziness, sleepiness, and even respiratory depression. Lyrica contains the active drug pregabalin, which isn’t an opioid.